May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Melanocytoma of the Iris and Ciliary Body: A Review of 54 Cases
Author Affiliations & Notes
  • H. Demirci
    Oncology Service, Wills Eye Hospital, Philadelphia, PA, United States
  • A. Mashayekhi
    Oncology Service, Wills Eye Hospital, Philadelphia, PA, United States
  • C.L. Shields
    Oncology Service, Wills Eye Hospital, Philadelphia, PA, United States
  • J.A. Shields
    Oncology Service, Wills Eye Hospital, Philadelphia, PA, United States
  • Footnotes
    Commercial Relationships  H. Demirci, None; A. Mashayekhi, None; C.L. Shields, None; J.A. Shields, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1551. doi:
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      H. Demirci, A. Mashayekhi, C.L. Shields, J.A. Shields; Melanocytoma of the Iris and Ciliary Body: A Review of 54 Cases . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1551.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To report the clinical characteristics, management, and outcome of melanocytoma of the iris and ciliary body. Methods: Retrospective case series. Results: The mean patient age was 34 years and 44 (83%) were Caucasian. Of 54 patients, 39 (72%) had iris melanocytoma and 15 (28%) ciliary body melanocytoma. The most common symptom was spot on iris in 11 patients (21%) and 21 patients (40%) were asymptomatic. Visual acuity was better than 20/40 in 48 patients (91%) and 5 patients (9%) had increased intraocular pressure (>21 mmHg). Of 39 patients with iris melanocytoma, the lesion was black in 38 patients (97%), nodular shaped in 34 (87%), associated with ectropion uvea in 4 (10%), stromal seeds in 21 (54%) and anterior chamber angle seeds in 17 patients (44%). Of 15 patients with ciliary body melanocytoma, the lesion was black in 15 patients (100%), dome shaped in 15 (100%), associated with anterior chamber angle seeds in 5 (33%)and anterior chamber involvement in 9 patients (60%). Ultrasonography showed acoustic solidity in 16 of 17 patients (94%). The treatment was observation in 28 patients (52%), excisional biopsy in 22 (41%) and enucleation in 4 (7%). At a mean follow-up of 43 months, visual acuity decreased in 11 patients (20%) and growth was observed in 11 patients (20%). Eleven patients were found to have foci of melanoma within melanocytoma on pathology. Conclusions: Melanocytoma of the iris and ciliary body is rare and can evolve into malignat melanoma.

Keywords: melanocytes • melanoma • oncology 
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