May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Increased Expression of Ciliary Neurotrophic Factor and the Signal Transducers and Activators of Transcription (STAT3) in the Developing FVB/N Mouse Retina
Author Affiliations & Notes
  • E. Lim
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • S. Park
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • S. Oh
    Anatomy, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • C. Park
    Ophthalmology, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • J. Chung
    Ophthalmology, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • M. Chun
    Ophthalmology, Catholic Univ Korea Coll Med, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  E. Lim, None; S. Park, None; S. Oh, None; C. Park, None; J. Chung, None; M. Chun, None.
  • Footnotes
    Support  Korea Research Foundation Grant 2001, FP0005
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 1615. doi:
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      E. Lim, S. Park, S. Oh, C. Park, J. Chung, M. Chun; Increased Expression of Ciliary Neurotrophic Factor and the Signal Transducers and Activators of Transcription (STAT3) in the Developing FVB/N Mouse Retina . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1615.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate the regulatory expression of ciliary neurotrophic factor (CNTF) and the signal transducers and activators of transcription (STAT3) in the retinal degeneration (rd) mouse. Methods: Retinas were removed from FVB/N mice at postnatal day (P) 12, 14, 16, 18, 21. Immunohistochemistry and western blot analysis were applied to identify expression and cellular localization of CNTF and STAT3. Results: In the normal developmental retina, CNTF immunoreactivity first appeared in Müller cells at P14, and then disappeared by P18. In the FVB/N retina, CNTF immunoreactivity was also appeared in Müller cells at P14, but its intensity was stronger. The immunoreactivity was continuously expressed up to P21. In the normal developmental retina, STAT3 immunoreactivity increase in Müller cells up to P16, and then disappeared. In the FVB/N retina, STAT3 immunoreactivity was also continuously expressed up to P21. Also CNTF, STAT3 quantitative evaluation by immunoblotting appear simialar pattern. Conclusions: These results suggest that Müller cells may play protective roles in the degenerative processes of FVB/N mouse via increased expression of endogenous neuroprotective system.

Keywords: retinal degenerations: cell biology • cytokines/chemokines • retinal glia 
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