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C. Francais, C. Favard, A. El Maftouhi, H. Naacke, G. Coscas, L. Larouche; Angiographic Characteristic Findings of Eyes Non-responding to Photodynamic Therapy for Subfoveal Choroidal Neovascular Membrane in Age Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1760.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine CNV angiographic characteristics of eyes non responding to Photodynamic Therapy with Verteporfin Material and Method: Retrospective study with two years of follow-up duration out of a series of 220 treated patients: 23 eyes were re-examined in case of decrease in visual acuity of 3 lines or, and more than 30% extension of CNV area. All patients included, after the first Photodynamic Therapy session were completely examined with ETDRS visual acuity testing and fluorescein angiography (and ICG angiography only at inclusion), at 6-week interval and after 3-month interval; presence of leakage or extension was noted. Results: All the 23 patients presented with subfoveal CNV, but slightly excentried from the center of fovea, dense hypo fluorescent halo, predominant classic CNV (more than 75%), few or absence of serous drusen (less than 5 serous drusen). At 6-week control 50% in extension area of CNV ( range 20% 190%) was observed in all patients , associated with decrease of visual acuity (mean loss of 3,5 lines). A progressive worsening was observed at 3-month control (average: extension of 130%, loss of 5.89 lines), and increased still after the second session (average: extension of 280%, loss of 7.62 lines). Conclusions: This group of patients with small recent sub foveal classic predominant CNV slightly excentried from the center of the fovea, associated with good inital vision could deserve a more close follow-up for early retreatment (VER study), and should benefit from alternative treatment
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