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P.E. Liggett, N. Chaudhry, D. Tom, H. Quiroz-Mercado, D. Alfaro, E. Jablon; ICG Enhanced-Transpupillary Thermotherapy for Choroidal Neovascularization in AMD . Invest. Ophthalmol. Vis. Sci. 2003;44(13):1771.
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Purpose: A preliminary study to test the effectiveness of ICG-enhanced TTT for the treatment of choroidal neovascularization from AMD Methods: Retrospective interventional pilot study using ICG as a chromophore and TTT Results: Twelve patients with AMD and subfoveal CNV who were not eligible for PDT/vertiporforin were treated. Six patients remained stable in terms of visual acquity with resolution of the CNV over a period of 1 year. Three patients developed either a recurrent CNV or their CNV worsened form the treatment with further loss of vision. Three patients had resolution of the CNV and improved vision 1 -3 Snellen lines. Conclusions: This preliminary study suggests that ICG-enhanced TTT may offer a useful adjuvant treatment for subfoveal CNV related to AMD, especially in patients who are not candidates for PDT/vertiporforin. A further large randomized clinical trial is required to determine the future usefulness of this treatment modality
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