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N. Maeda, T. Kuroda, S. Ninomiya, T. Fujikado, Y. Tano, Y. Hirohara, T. Mihashi; Prediction of Visual Function With Higher-Order Wavefront Aberrations Using Multivariate Analysis of Zernike Terms . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2087.
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Purpose: To predict the visual function with higher-order aberrations using multivariate analysis of Zernike terms, and to compare the results with linear regression using total higher-order aberrations. Methods:Wavefront sensing was performed with the KR-9000PW (Topcon, corp., Japan) on 140 normal, post-LASIK, post-PRK, and keratoconus eyes. The magnitudes of the coefficients of the Zernike polynomials were determined for a 4 mm diameter pupil up to the fourth order, and data from the left eyes were adjusted to avoid the effect of enantiomorphism. For the visual function, high contrast visual acuity (100%ETDRS), low contrast visual acuity (10%ETDRS), Letter contrast sensitivity (LCS), and area under the log contrast sensitivity function (AULCSF) were measured under full correction. To predict the visual function, multiple regression analysis of Zernike terms, or linear regression analysis of total higher-order aberrations were performed.Results:Regression coefficients with multiple regression using Zernike terms were better than those with linear regression using total higher-order aberrations (100% ETDRS: 0.72 vs. 0.58, 10% ETDRS: 0.74 vs. 0.61, LCS: 0.80 vs. 0.67, AULCSF: 0.77 vs. 0.65). Forward stepwise regression analysis demonstrated that the terms inside the Zernike pyramid such as coma and secondary astigmatism were more important than terms outside the Zernike pyramid.Conclusions:Our results suggest that each Zernike term in the higher-order aberrations affects the visual functions differently. To evaluate the optical quality of eyes with wavefront sensing, not only the total amount of higher-order aberrations but also the magnitudes of the each coefficient of the Zernike polynomials should be considered.
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