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L. Wang, E. Dai, D.D. Koch; Optical Aberrations of the Human Cornea . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2091.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: 1) To investigate the distribution of corneal higher-order aberrations (HOAs, 3rd order to 6th order) in the population, 2) to evaluate the symmetry of the corneal aberrations between right and left eyes of each individual, and 3) to study the changes in corneal aberrations with aging. Methods: Using the CTView program (Sarver and Associates, Inc., Merritt Island, FL), corneal HOAs were computed from the central 6-mm zone on the corneal topographic maps (Humphrey Atlas) in 228 eyes of 134 subjects (mean age: 50 ± 17 (SD) years, range 20 to 79 years old; manifest spherical equivalent between –3 and +3 D). Correlation analysis was performed to investigate the aberration symmetry between the right and left eyes and to assess the association between corneal HOAs and age. Results: There was a wide individual variability in aberrations with ranges of individual Zernike terms from -0.577 to +0.462 µm. The mean coefficient of 4th-order spherical aberration (SA) (Z40) term was 0.221 ± 0.079 µm and was positive for all corneas. The mean root-mean-square (RMS) values were 0.381 ± 0.096 µm for HOA, 0.221 ± 0.079 µm for SA (Z40 and Z60), and 0.203 ± 0.109 µm for coma (Z3-1, Z31, Z5-1 and Z51). Moderate to high correlations were found between the right and left eyes for HOA, SA and coma (Pearson correlation coefficient r = 0.574, 0.840 and 0.573, respectively, all P<0.001); 13 out of the 22 Zernike terms (59%) were significantly correlated between eyes (Bonferroni correction, P’<0.05/22). HOA RMS and coma RMS increased with aging (r = 0.334 and 0.247, respectively, both P<0.006), whereas SA RMS was not correlated with change in age(r = -0.002). Conclusions: Corneal wavefront aberrations varied greatly among subjects and increased slightly with aging. All corneas had positive 4th-order SA and the values did not change with aging. A moderate to high degree of mirror symmetry existed between the right and left eyes.
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