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J.F. Koretz, J.C. Salerno; Homology Modeling of Alpha-crystallin: Analysis of a Conserved N-terminal Structural Motif and its Interaction with the Central Core . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2373.
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Purpose: To investigate the functional role and potentially conserved structural motifs of the N-terminal region of alpha-crystallin that precedes the central core, based on analogies to other members of the small heat shock protein superfamily. Methods: Primary sequence alignments of representative samples were initially generated using the programs PILEUP and CLUSTAL W and the pairwise alignment program ALINORM, then further refined manually. The homology model of alphaA-crystallin was derived from the crystallographic structures of methanococcus HSP 16.5 and wheat HSP 16.9. View OriginalDownload SlideView OriginalDownload Slide
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