May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Treatment of Conjunctival Squamous Cell Carcinoma with Photodynamic Therapy - First Results
Author Affiliations & Notes
  • I.A. Barbazetto
    E Harkness Eye Inst, Columbia University, New York, NY, United States
  • T.C. Lee
    Weill-Cornell Medical Center, Cornell University, New York, NY, United States
  • I. Rollins
    Ophthalmology, Cornell University, New York, NY, United States
  • D.H. Abramson
    Ophthalmology, Cornell University, New York, NY, United States
  • Footnotes
    Commercial Relationships  I.A. Barbazetto, None; T.C. Lee, None; I. Rollins, None; D.H. Abramson, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2435. doi:
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      I.A. Barbazetto, T.C. Lee, I. Rollins, D.H. Abramson; Treatment of Conjunctival Squamous Cell Carcinoma with Photodynamic Therapy - First Results . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2435.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To report first results of a study treating conjunctival squamous cell carcinoma (SCC) with photodynamic therapy (PDT). Methods: Three patients with squamous cell carcinoma of the conjunctiva were treated with PDT in a prospective study. Patients received a single treatment of verteporfin (6mg/m2 BSA, i.v.). The light dose was calculated as 50 J/cm2 tumor surface area. Standard ophthalmic examination including slit-lamp biomicroscopy, color photography and fluorescein angiography before and after treatment, was evaluated. The main outcome-measurements were clinical response and treatment related side-effects. Results: In two out of three cases the tumor involved the limbus and the cornea. One case was a recurrence after previous surgery. The caruncle was involved in one eye. Tumor regression in the treated area was noted in all patients one months post treatment with complete regression and no recurrence over 5 months in one patient. PDT caused moderate temporary local irritation in two patients (1 week), small conjunctival hemorrhage and transient chemosis in the three eyes. One patient had infusion-related back pain. Conclusions: Preliminary evidence suggests that PDT may be a valuable addition to the treatment spectrum for patients with squamous cell carcinomas of the conjunctiva. Longer follow-up is necessary to assess the duration and degree of tumor control.

Keywords: conjunctiva • tumors • photodynamic therapy 
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