May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Prophylactic Mitomycin-C for High-Risk PRK and LASEK
Author Affiliations & Notes
  • E.M. Candal
    Ophthalmology, Rush-Pres.-St. Luke's Med. Center, Chicago, IL, United States
  • L.T. Muller
    Ophthalmology, Rush-Pres.-St. Luke's Med. Center, Chicago, IL, United States
  • H.A. Lane
    Ophthalmology, Rush-Pres.-St. Luke's Med. Center, Chicago, IL, United States
  • R.J. Epstein
    Ophthalmology, Rush-Pres.-St. Luke's Med. Center, Chicago, IL, United States
  • R.F. Dennis
    Ophthalmology, Rush-Pres.-St. Luke's Med. Center, Chicago, IL, United States
  • P.A. Majmudar
    Ophthalmology, Rush-Pres.-St. Luke's Med. Center, Chicago, IL, United States
  • Footnotes
    Commercial Relationships  E.M. Candal, None; L.T. Muller, None; H.A. Lane, None; R.J. Epstein, None; R.F. Dennis, None; P.A. Majmudar, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2616. doi:
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      E.M. Candal, L.T. Muller, H.A. Lane, R.J. Epstein, R.F. Dennis, P.A. Majmudar; Prophylactic Mitomycin-C for High-Risk PRK and LASEK . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2616.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To determine the incidence of subepithelial haze in patients with high myopia undergoing photorefractive keratectomy (PRK) or laser assisted epithelial keratomileusis (LASEK) with prophylactic administration of Mitomycin-C (MMC). Methods: Forty-seven eyes of twenty-four patients with a mean pre-operative spherical equivalent (S.E.) of -5.87 D underwent routine PRK or LASEK using a VISX S2 (n=23), VISX S3 (n=8), or Technolas 217 excimer laser (n=16) using a modified nomogram. All eyes received a single intra-operative application of MMC (0.02%) following laser ablation, according to our previously published protocol. Results: Mean postoperative S.E. was -0.56 D (range -1.25 to +2.50 D). Five eyes (10.6%) developed visually insignificant haze (mean 0.07 with haze score range 0 to 4) during a mean follow up of 8.5 months (range 3 to 27). No eyes developed delayed reepithelialization or toxicity. Conclusions: Administration of prophylactic MMC during high-risk PRK or LASEK resulted in a low incidence of haze and was associated with good refractive and visual outcomes.

Keywords: refractive surgery • refractive surgery: PRK • cornea: stroma and keratocytes 
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