Purchase this article with an account.
E.M. Candal, L.T. Muller, H.A. Lane, R.J. Epstein, R.F. Dennis, P.A. Majmudar; Prophylactic Mitomycin-C for High-Risk PRK and LASEK . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2616.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine the incidence of subepithelial haze in patients with high myopia undergoing photorefractive keratectomy (PRK) or laser assisted epithelial keratomileusis (LASEK) with prophylactic administration of Mitomycin-C (MMC). Methods: Forty-seven eyes of twenty-four patients with a mean pre-operative spherical equivalent (S.E.) of -5.87 D underwent routine PRK or LASEK using a VISX S2 (n=23), VISX S3 (n=8), or Technolas 217 excimer laser (n=16) using a modified nomogram. All eyes received a single intra-operative application of MMC (0.02%) following laser ablation, according to our previously published protocol. Results: Mean postoperative S.E. was -0.56 D (range -1.25 to +2.50 D). Five eyes (10.6%) developed visually insignificant haze (mean 0.07 with haze score range 0 to 4) during a mean follow up of 8.5 months (range 3 to 27). No eyes developed delayed reepithelialization or toxicity. Conclusions: Administration of prophylactic MMC during high-risk PRK or LASEK resulted in a low incidence of haze and was associated with good refractive and visual outcomes.
This PDF is available to Subscribers Only