May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Avellino Dystrophy after Laser in situ Keratomileusis
Author Affiliations & Notes
  • E. Kim
    Ophthalmology, Institute of Vision Research, Brain Korea 21, Division of Medical Science, Yonsei Univ College of Med, Seoul, Republic of Korea
  • S.E. Jung
    Ophthalmology, Institute of Vision Research, Brain Korea 21, Division of Medical Science, Yonsei Univ College of Med, Seoul, Republic of Korea
  • R.M. Jun
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of Med, Seoul, Republic of Korea
  • J.H. Lee
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of Med, Seoul, Republic of Korea
  • K.Y. Seo
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of Med, Seoul, Republic of Korea
  • J.B. Lee
    Ophthalmology, Institute of Vision Research, Yonsei Univ College of Med, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  E. Kim, None; S.E. Jung, None; R.M. Jun, None; J.H. Lee, None; K.Y. Seo, None; J.B. Lee, None.
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 2672. doi:
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      E. Kim, S.E. Jung, R.M. Jun, J.H. Lee, K.Y. Seo, J.B. Lee; Avellino Dystrophy after Laser in situ Keratomileusis . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2672.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: . To report Avellino corneal dystrophy cases that exacerbated after uncomplicated laser in situ keratomileusis (LASIK) for myopia and a case severely exacerbated after mechanical removal of the granular material from the interface after LASIK. Methods: Six patients with recurrent corneal dystrophy showing granular deposits at the interface after LASIK were examined for BIGH3 mutations by PCR sequencing of DNA. One patient of heterozygous Avellino dystrophy exacerbated and previously reported was followed up for 16 months after removal of granular deposit from the interface for the observation of the recurrence of the opacities Results: All patients were confirmed to have heterozygous Avellino dystrophy gene. Best spectacle-corrected visual acuity decreased with the progression of opacities. Avellino dystrophy became severely exacerbated in 6 months after mechanical removal of the granules from the interface. Conclusions: LASIK is contraindicated in patients with Avellino dystrophy because it aggravates corneal lesions of previously mild deposits and induces decrease of the best corrected visual acuity of the patients. Mechanical removal of the material deposited at the interface is not recommended.

Keywords: cornea: clinical science • refractive surgery: complications • gene/expression 
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