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M. Moschos, D. Panayiotidis, G. Theodosiadis, E. Synodinos, E. Georgiadou, M.N. Moschos; Assessment of Macular Function by mf-ERG in Patients with Choroidal Neovascularization due to Pathologic Myopia before and after Photodynamic Therapy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2697.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Pathologic myopia has been reported to be a major cause of blindness in the United States. Many of these cases of visual loss are the result of the development of choroidal neovascularization (CNV). Photodynamic therapy (PDT) is widely used in order to treat subfoveal CNV due to pathologic myopia.The purpose of this study is to evaluate the macular function by means of mf-ERG before and after PDT in patients with classic subfoveal CNV due to pathologic myopia. Methods: 10 eyes of 10 patients (6 male, 4 female) with classic subfoveal CNV due to pathologic myopia were studied. Pathologic myopia was defined as an eye requiring a distance correction of at least –6.0 diopters (D: spherical equivalent). All patients received Verteporfin therapy. Fluorescein angiography and mf-ERG were performed in each patient 1 day before and 1 week, 3 and 6 months after PDT treatment. Best-corrected visual acuity was measured on a Bailey-Lovie chart using a standardized refraction protocol. For the recording of mf-ERG the VERIS III was used. Results: The mean visual acuity before PDT was 45 (SD 7,318). The mean retinal response density (RRD) before PDT in area 1 was 4.12 nV/deg2 (SD 2.121) and in area 2 1.997 nV/deg2 (SD 1.793). Six months after treatment fluorescein angiography shows no CNV leakage in all cases. The mean visual acuity after PDT was 51.6 (SD 8,302). The mean retinal response density (RRD) after PDT in area 1 was 5.562 nV/deg2 (SD 3.6) and in area 2 2.43 nV/deg2 (SD 2.366). Conclusions: mf-ERG evaluates objectively the macular function of myopic eyes with CNV. After successful PDT, the electrical activity of the foveal and perifoveal area is higher than before treatment. This finding postulates the efficacy of PDT in the treatment of the disease.
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