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G. Corgiat Mecio, A. Fea, A. Bertolotto, S. Malucchi, A. Morra, G. Marzo, F. Vitale Brovarone, F.M. Grignolo; Chromatic VEP in Multiple Sclerosis . Invest. Ophthalmol. Vis. Sci. 2003;44(13):2716.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Multiple sclerosis (MS) is a complex and invalidating disease. The relative damage of the magno vs parvo-cellular pathway in multiple sclerosis is still debated. Investigation of the selective damage can enhance our understanding of the pathophysiological mechanisms implicated in the disease and eventually help to develop more sensitive tests. Methods: Stimuli were presented on a Trinitron Sony monitor (17') and were generated by the VSG2/3 system. They consisted in opponent chromatic sinusoidal gratings: red (CIE x=0,4033 e y= 0,2811) - green (x=0,2223 e y=0,3663) ; yellow (x=0,3554 e y=0,4142) and blue (x=0,2702 e y=0,2332) and in luminance opponent stimuli: yellow and black. On-off VEP (300-700 msec) were recorded using the BM6000 system. At least 100 events were recorded in 24 patients who had previous episodes of optic neuritis and in 32 age-matched subjects. VA was higher than 7/10, Results: Color opponent VEP had significantly lower amplitudes and significantly more delayed implicit times than luminance opponent VEP in MS patients (p<0.01). Significan differences for both amplitude and implicit times were evident when comparing MS patients to controls only when red-green stimuli were used (p<0,01) Conclusions: The red-green opponent pathway seems to be damaged in the MS patients more than the blue-yellow and the luminance opponent pathways.
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