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M.S. Benz, E.M. Escalona-Benz, T.G. Murray, C.W. Eifrig, D.M. Yoder, J.K. Moore, V. Cruz-Villegas; Immediate Postoperative Use of a Single Topical Agent to Prevent Intraocular Pressure Elevation after Pars Plana Vitrectomy with Long-acting Gas Tamponade . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3014.
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Purpose: To determine whether a single topical aqueous suppressant applied immediately after pars plana vitrectomy with gas tamponade prevents intraocular pressure (IOP) elevation. Methods: Sixty patients who met inclusion criteria and underwent pars plana vitrectomy with long-acting gas tamponade were randomized to receive one drop of timolol/dorzolamide (Cosopt), one drop of long-acting timolol (Timoptic XE), one drop of dorzolamide (Trusopt), or placebo at the conclusion of surgery. Intraocular pressure was checked by Tono-pen at the conclusion of surgery, approximately five hours after surgery, one day after surgery, and one week after surgery. Results: Fifteen patients were enrolled in each group. There was no significant difference in IOP between the groups at the conclusion of surgery. The IOP measured at approximately 5 hours after surgery (26.7 [control], 14.8 [timolol/dorzolamide]) and one day after surgery (25.5 [control], 16.8 [timolol/dorzolamide]) showed a statistically significant difference between the placebo and timolol/dorzolamide groups both at 5 hours (P < 0.001) and at one day (P < 0.001). The combination timolol/dorzolamide group showed greater IOP control than either the timolol or dorzolamide groups. Conclusions: The use of a single topical aqueous suppressant (timolol/dorzolamide) given immediately after pars plana vitrectomy with long-acting gas tamponade effectively prevents significant postoperative IOP elevation at both five hours and one day after surgery.
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