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O.M. Bjornsson, B. Kinge, P. Syrdalen, A.C. Bird, I. Leung, T. Peto; The Prevalence of Age Related Maculopathy (ARM) in an Urban Norwegian Population – Oslo Macular Study . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3082.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To examine the prevalence of age-related maculopathy and age-related macular degeneration in citizens 51 years and older of Oslo and surroundings, not previously described. Methods: Random sample of 800 people selected by the Norwegian National Registrar creating a cross sectional study design. A total of 459 participants who resided at the given address and agreed to the study were photographed of a total sample of 800. Of the 341 not available, 30 were either diseased or had changed address, 49 refused to participate and 262 did not respond at all. Stereoscopic color digital photographs were obtained and subsequently graded at a certified reading center using the International classification grading system for ARM and AMD1. A total of 453 right and 451 left macular images could be evaluated and graded and there was no statistically significant difference between right and left eyes. Early ARM was classified as presence of soft, indistinct or reticular drusen >63µ within the grid and/or presence of retinal pigment epithelial abnormalities >63µ. Results: Intermediate soft drusen 63-125µ were found in either eye in 26.9% (95% CI 19.9-33.8) in people aged 51-60 years and 23.4% (95% CI 10.8-35.9) for those 81-90 years of age. Soft distinct drusen >125µ were found in either eye in 1.3% (95% CI 0.0-2.9) in people aged 51-60 years and 2.1% (95% CI 0.0-6.4) in people aged 81-90 years. Large soft indistinct, crystalline or semisolid drusen were found in either eye in 5.6 % (95% CI 2.0-9.2) in people aged 51-60 years and 40.4% (95% CI 25.8-54.9) in people aged 81-90 years. Any pigment change in either eye was found in 37.5% (95% CI 29.9-45.0) in people aged 51-60 years and 72.3% (95% CI 59.0-85.6) in people aged 81-90 years. Early ARM in either eye was found in 65.4% (95% CI 61.0-69.8) in people aged 51 years and older. In people 71 years and older geographic atrophy was found in either eye in 3.6% (95% CI 0.4-6.8) and exudative macular degeneration was found in 2.9% (95% CI 0.0-5.7). Conclusion: Early ARM had a higher prevalence than previously reported in other populations. AMD had the same prevalence as described in the literature; a greater proportion had GA than is reported in other surveys.
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