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M. Tamai, Rsrch Group of Low-Dose Radiation Therapy for AMD; The Results of Randomized Controlled Trial (RCT) of Low-Dose Radiation for Wet-Type Age-Related Macular Degeneration on 1 Year Term Basis . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3157.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: We report the validity and outcome that the effect of low dose radiation therapy to visual loss in patients with subfoveal choroidal neovascularization (CNV) in wet-type age-related macular degeneration (wet-AMD) on short-term period was evaluated with the randomized controlled trial (RCT) under the support of the Ministry of Health, Labor and Welfare. Methods: In the RCT on low-dose radiotherapy, patients were irradiated with 10 fraction of 2Gy external beam irradiation (total 20 Gy) or just observed. 68 cases with CNV smaller than 1 disk diameter located within 200 micrometer from the fovea and vision better than 0.1 were allocated into 38, the treatment group, and 30, the control group. Between the treated and non-treated group, there was no significant difference in gender, age, initial visual acuity and sizes of the CNV. Results: With the follow-up for of 12 months, in the treated group, the visual acuity was significantly well preserved. Vision (logMAR) was kept at 6 * and 12 months** better than control group (p=0.0436*, p=0.0179**). And the size of CNV, with the follow-up for of 6 months, was decreased better than control group (p=0.0198***). So the vusual acuity was significantly well preserved and the size of CNV was decreased. Conclusion: The findings suggest a beneficial effect of low-dose radiation for preservation of vision and regression of CNV (*, **, ***p<0.05). These results indicate that low dose irradiation is effective for the wet-type AMD of the stage we indicated in the present study on 1-year term basis.
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