Purchase this article with an account.
P.J. Foster, D. Machin, T. Wong, J.F. Kirwan, P.T. Khaw, S.K. Seah; Determinants of Intraocular Pressure and its Association with Glaucomatous Optic Neuropathy in Chinese Singaporeans: The Tanjong Pagar Survey . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3410.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To describe the relationship between intraocular pressure (IOP) and various anthropomorphic, demographic, socio-economic, systemic and ocular factors. Methods: IOP was estimated using Goldmann applanation tonometry. The drainage angle was assessed using static and dynamic gonioscopy in low-light conditions, to grade width of the drainage angle, and identify areas of peripheral anterior synechiae (PAS). The optic nerve was examined at high magnification through a dilated pupil using a fundus contact lens. Static automated (Humphrey) visual field testing was carried out on subjects suspect of having glaucoma. Glaucoma was diagnosed on the basis of structural and functional abnormalities of the optic nerve. Multiple linear and logistic regression were used to test association between risk factors and IOP or glaucoma. Results: Higher systolic blood pressure (P< 0.001), more quadrants of PAS (P= 0.02) and narrower width of drainage angle (P= 0.049) and greater corneal thickness were the only significant, independent determinants of higher IOP. A 100 µm increase in corneal thickness was associated with an increase in mean IOP of 1.5 to 1.8 mm Hg (P< 0.001). No other significant associated factors were identified. Odds of GON increased 1.2 times per mm Hg rise in screening IOP. Conclusions: IOP estimates vary with systolic blood pressure and corneal thickness, the latter probably as a source of measurement error. Variation in IOP with angle width may suggest that trabecular compaction significantly contribute to causes of IOP increase independent of angle-closure. Glaucoma is an IOP-related phenomenon among Chinese Singaporeans.
This PDF is available to Subscribers Only