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J. Jung, Y. Kim, Y. Chung, J. Kim, Y.S. Yu; The Association of Clusterin With Ischemic Damage in Oxygen Induced Retinopathy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3568.
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Purpose: To determine whether clusterin is associated with ischemic damage in oxygen induced retinopathy Methods: 7-day-old C57BL mice were kept under hyperoxic condition (75-80 % oxygen) at 23°C for 5 days. Pups were returned to normal condition at postnatal day (P) 12. At P12, 14, 18, 26, pups were sacrifice. Immunohistochemistry and Western blotting for flt-1/flk-1 and clusterin were performed. The extent of angiogenesis was measured with time sequence. Results: The immunoreactivity of clusterin was prominent in inner retina, where flt-1/flk-1 was expressed, and was temporally associated with flt-1/flk-1 expression. The quantitative change of clusterin was proportional to that of angiogenesis. Conclusions: Clusterin is expressed in association with retinal ischemic damage. It may play a role in retinal angiogenesis.
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