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B. Long, S. Dillehay, J.T. Barr, P. Bergenske, P. Donshik, G. Secor, J. Yoakum; Biomicroscopy Signs and Subjective Symptoms through 6 Months among Patients Wearing a High Dk Silicone Hydrogel Soft Contact Lens . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3712.
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Purpose: To report changes in a range of biomicroscopy signs and subjective symptoms through 6 months among patients dispensed to wear a lotrafilcon A high oxygen permeable (HDk) silicone hydrogel soft contact lens (SCL).Methods: 19 sites in the US fitted and dispensed 317 patients for bilateral wear of HDk silicone hydrogel SCLs. Biomicroscopy grades for 9 signs using a 0 (none) – 4 (severe) scale and frequency and severity of 10 subjective symptoms using a 0 (none) to 3 (every day or severe) scale were taken at dispensing, 1-week, 1 and 6-months. 286 patients were habituated, current contact lens wearers and 31 patients were either former or new wearers. Grades for biomicroscopy signs were averaged between eyes.Results: On average, reductions were seen for 7 of 9 biomicroscopy signs among habituated contact lens wearers and 6 of 9 biomicroscopy signs among non-wearers. Biomicroscopy signs of conjunctival redness and limbal redness showed the greatest change among habituated wearers. Average biomicroscopy signs among new wearers increased 0.1 through 6 months. Reductions in frequency for 9 of 10 subjective symptoms were reported by experienced wearers while reductions and increases in frequency were equally balanced for new wearers. The average reduction in frequency of subjective symptoms for experienced wearers was greatest between dispensing and 1-week follow-up. The largest change in frequency of symptoms for both experienced and new wearers was for tearing or watering. Reductions in severity for 9 of 10 subjective symptoms were reported by experienced wearers with equal increases and decreases in severity reported by new wearers. On average, experienced wearers reported more changes between dispensing and 1-week than at other follow-up visits. Severity of subjective symptoms were stable over 6 months of follow-up with an average improvement of 0.1. Thirty-seven (12%) patients discontinued the trial over 6 months.Conclusions: Improvements for a wide range of clinical signs and subjective symptoms may be seen among patients dispensed in HDk lenses. The effect of improved corneal oxygenation for soft contact lens wearers may benefit eye health and patient satisfaction.
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