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N. Harizman, M. Belkin, M. Rosner; The Effect of Healon5 on the Healing Speed of Corneal Erosions in an Animal Model . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3826.
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Purpose: Hyaluronic acid was proved to enhance corneal re-epithelization in vitro and in vivo. Healon5, a new drug based on hyaluronic acid, is used to protect endothelial cells during intraocular surgery. An animal model study was conducted to evaluate the effect of healon5 on the healing speed of corneal erosions. Methods: Corneal erosions, six millimeter in diameter, were induced in one eye of 15 rabbits. Five rabbits were treated with healon5, five rabbits with Chloramphenicol 5% ointment and five other rabbits served as the untreated control group. The corneas were evaluated, photographed and treated at 8 hour intervals until full healing of the erosion was observed. The erosion area was calculated from photographs using a computerized photograph analyzer. After the erosion was completely healed, the rabbits were sacrificed and histopathologic examination of the corneas was performed. Results: The mean healing time of the corneal erosions was 82 hours for the group treated by Healon5, 68.8 hours for the Chloramphenicol 5% ointment treatment group, and it was the shortest, 54.4 hours, in the untreated control group. The differences between the Healon5 or the ointment treatment groups and the untreated control group were statistically significant (t test: P=0.00003, P=0.05, respectively). The histopathologic evaluation of the healed corneas revealed no significant difference between the three groups. Conclusions: Healon5 caused a significant delay in the healing of corneal erosions, and thus it is not suitable for artificial bandaging of corneal erosions. It was shown that ointments such as Chloramphenicol 5% also delayed the healing of corneal erosions compared to the rate of healing with no treatment at all.
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