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P.D. Ramalho, A. Pereira da Silva, C. Nobrega, I. Osório, T. Quintão, M. P. Bicho; The Role of Epinephrine Oxidase (EpOx) and Protein Tyrosine Phosphatase (ACP1) in Diabetic Retinopathy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):3917.
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Purpose: To study the ACP1 and EpOx activities in diabetic patients with and without retinopathy, compared with healthy controls Methods: 92 subjects, 50 healthy, and 42 with diabetes (type I=3 and type II=39) of both sexes, adjusted for age were studied. Seventeen diabetics had retinopathy. The ACP1 (mmol/gHb/h) and EpOx (mmol/ml/h) activities were determined by spectrophotometric methods. The statistical methods used were ANOVA, t Student and Pearson correlation Results: The ACP1 activity is increased in diabetic patients (384,193 ± 138,83) compared to normals (188,63±43,17) p<0,001, but didn't show any significant differences between the groups with and without retinopathy, 403,40 ± 119,73 vs. 372,84 ± 150,51 (NS). However, the EpOx activity in diabetics (43,96±12,16) was greater in the group without retinopathy (47,41±11,17) vs. with retinopathy (37,62±11,74), p=0,022. The ACP1 and EpOx activities were inversely correlated in diabetics with retinopathy p=0,018; r= -0,666; and directly in the absence of this complication p=0,018; r=0,499. Conclusions: We confirm the increased activity of ACP1 in diabetes. The EpOx, with greater activity in absence of retinopathy, was directly correlated with ACP1 in these subjects and inversely in retinopathy patients, probably reflecting a closer relationship between these enzymes. Further studies are needed.
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