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J. Tang, V.A. Deramo; The Incidence of Central Retinal Vein Occlusions in Patients on Systemic Anticoagulation with Aspirin or Warfarin . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4040.
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Purpose: The purpose of this study was to evaluate the incidence of patients on systemic anticoagulation with aspirin or warfarin who presented with central retinal vein occlusions (CRVO). Methods: This was a retrospective consecutive case series in which we analyzed patients who were diagnosed with CRVO from January 2002 to December 2002. All patients were evaluated with best corrected Snellen visual acuity, biomicroscopy, and fluorescein angiography (FA) at the time of presentation. Baseline best corrected visual acuity, duration of symptoms, past medical/ocular history and use of anticoagulants were noted. Results: Twenty-four eyes of 24 patients who had a new diagnosis of CRVO were identified. Patients were symptomatic for 3 months on average prior to presentation. Of the 24 patients, 13 (54%) were female. The mean age was 69 years (range 26-95 years). Sixteen (66%) patients had preexisting hypertension, 4 (17%) patients had diabetes and 6 (25%) patients had high cholesterol by history. Five (20%) patients had open angle glaucoma. Nine (38%) of the 24 patients were on aspirin and 2 (8%) were on warfarin, both with therapeutic INR values (> 2.0) at the time of CRVO development. Seven (30%) of the 24 patients were treated with pan-retinal photocoagulation. Five (70%) of these 7 treated patients were on aspirin on presentation. Conclusions: Systemic anticoagulation with either aspirin or warfarin did not prevent the occurrence of CRVO in our study patients.
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