May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Indocyanine Green-mediated Photothrombosis as a New Technique of Treatment for Persistent Central Serous Chorioretinopathy
Author Affiliations & Notes
  • L. Scapucin
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • R.A. Costa
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • N.S. Moraes
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • D. Calucci
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • L.A. Melo Jr
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • J.A. Cardillo
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • M.E. Farah
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • Footnotes
    Commercial Relationships  L. Scapucin, None; R.A. Costa, Akorn, Inc. C; N.S.B. Moraes, None; D. Calucci, None; L.A. Melo Jr, None; J.A. Cardillo, Akorn, Inc. C; M.E. Farah, Akorn, Inc. C.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4060. doi:
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      L. Scapucin, R.A. Costa, N.S. Moraes, D. Calucci, L.A. Melo Jr, J.A. Cardillo, M.E. Farah; Indocyanine Green-mediated Photothrombosis as a New Technique of Treatment for Persistent Central Serous Chorioretinopathy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4060.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate the potential benefit and complications of indocyanine green-mediated photothrombosis (IMP) in the management of patients with persistent central serous chorioretinopathy (CSC). Methods: Interventional noncomparative case series. Eleven patients with CSC presenting with persistent subretinal fluid in optical coherence tomography (OCT) four months after presentation and decrease in visual acuity (VA) were submitted to a single IMP session with 2 mg/kg body weight ICG and application of 5.6 W/cm2 light at 810 nm. A continuous follow-up was provided with best-corrected ETDRS VA assessment, and angiographic and OCT documentation 72 hours before and at 2 days, 1 and 2 weeks, 1, 3, 6, and 12 months after treatment. Results: Pretreatment VA levels ranged from 20/32-1 to 20/100 (mean, 20/63+2 [logMAR equivalent, 0.460 ± 0.155]); post treatment levels ranged from 20/25-2 to 20/20 (mean, 20/20-2 [logMAR equivalent, 0.038 ± 0.048]). Ten out of eleven patients presented with VA levels of 20/25 or more 2 weeks after treatment; the mean logMAR VA change of 0.345 at that time was statistically significant (p<0.05, Friedman test). OCT disclosed resolution of persistent subretinal fluid in all eyes. No recurrence was observed after 12 months of follow-up. Complications included transient retinal whitening in two patients, and associated occlusion of retinal capillaries in one. Conclusions: Photothrombosis using low-intensity 810 nm light to direct laser energy continuously at the active leakage sites after intravenous ICG infusion induced rapid VA recovery in patients with persistent CSC; accordingly, restoration of the macular architecture was evidenced on OCT, and no recurrence was noted 12 months after IMP.

Keywords: choroid • clinical (human) or epidemiologic studies: tre • laser 
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