May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Comparative Study of CLUL1, a Cone Photoreceptor Cell-specific Protein
Author Affiliations & Notes
  • Q. Zhang
    Dept. of Cell Biology, Oklahoma University Health Science Center, Oklahoma City, OK, United States
  • W. Beltran
    Baker Institute, Cornell University, Ithaca, NY, United States
  • J. Johnson
    Baker Institute, Cornell University, Ithaca, NY, United States
  • G. Acland
    Baker Institute, Cornell University, Ithaca, NY, United States
  • G. Aguirre
    Baker Institute, Cornell University, Ithaca, NY, United States
  • Footnotes
    Commercial Relationships  Q. Zhang, None; W. Beltran, None; J. Johnson, None; G. Acland, None; G. Aguirre, None.
  • Footnotes
    Support  by NEI/NIH grants EY06855, EY13132
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4256. doi:
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      Q. Zhang, W. Beltran, J. Johnson, G. Acland, G. Aguirre; Comparative Study of CLUL1, a Cone Photoreceptor Cell-specific Protein . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4256.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To characterize the expression of CLUL1 in light and dark adapted retinas. To compare expression of clusterin and CLUL1 in retina. Methods: We used a comparative approach to analyze expression of clusterin (CLU) and retinal clusterin-like protein (CLUL1) in the retinas of different developmental stages and of diseases by northern analysis. We also studied its expression by western analysis and localization by immunocytochemistry in light and dark-adapted retinas. Results: Although CLU and CLUL1 share certain degree of homology in amino acid sequences, our data demonstrate that they present totally different expression profiles in tissues, during retinal development and in retinal diseases. With a polyclonal antibody, we detected a 55kDa protein in retina and localized CLUL1 to outer segment of cone photoreceptor cells in light-adapted retina and to cone synaptic terminals in the dark-adapted retins. Conclusions: CLUL1 represents a potentially important gene in cone photoreceptor function, and a candidate gene locus for retinal disease.

Keywords: gene/expression • photoreceptors • retina: proximal(bipolar, amacrine, and gangli 
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