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S. Kusaka, R. Makino, M. Ohji, M. Kamei, Y. Ikuno, F. Gomi, Y. Saito, A. Hayashi, Y. Tano; Long-term Results of Pars Plana Vitrectomy with or without Removal of Internal Limiting Membranes on Diabetic Macular Edema . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4287.
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Purpose: To investigate the long-term results pars plana vitrectomy with or without removal of the internal limiting membrane (ILM) on diffuse diabetic macular edema. Methods: Ninety-four eyes of 74 patients with diffuse macular edema underwent a three-port pars plana vitrectomy with removal (Group A, 37 eyes of 30 patients, mean age 62.2 years) or without removal (Group B, 57 eyes of 44 patients, mean age 61.4 years) of the ILM. Preoperative, 1- and 2-year postoperative LogMAR visual acuities (VAs) were compared. Also, postoperative changes in foveal thickness measured by OCT (Humphrey Instrument) were evaluated. There were no statistical differences in age, sex, and preoperative VA between the 2 groups. Results: The mean foveal thickness (µm) was significantly decreased from 399 and 478 preoperatively to 271 and 227 one-year postoperatively, in both Group A (p=0.0002, paired-t test) and B (p=0.002), respectively. In Group A, the mean LogMAR VA was significantly improved from 0.76 preoperatively to 0.56 and 0.59 one-year and two-year postoperatively (P=0.001,One-Way ANOVA), respectively. However there was no statistical difference among preoperative, one-year, and two-year postoperative mean LogMAR VAs in Group B(P=0.946). Conclusion: Pars plana vitrectomy may be effective in improving macular edema in eyes with diffuse diabetic macular edema. In addition, removal of ILM seems to be effective in long-term VA improvement.
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