May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Comparison of the Additive Ocular Hypotensive Effect of Bimatoprost or Travoprost to Latanoprost in Glaucomatous Monkey Eyes and the Effect of Each on Outflow Facility in Normal Monkey Eye
Author Affiliations & Notes
  • D.J. Gagliuso
    Ophthalmology, Mount Sinai Medical Center, New York, NY, United States
  • R. Wang
    Ophthalmology, Mount Sinai Medical Center, New York, NY, United States
  • T.W. Mittag
    Ophthalmology, Mount Sinai Medical Center, New York, NY, United States
  • S.M. Podos
    Ophthalmology, Mount Sinai Medical Center, New York, NY, United States
  • Footnotes
    Commercial Relationships  D.J. Gagliuso, None; R. Wang, None; T.W. Mittag, None; S.M. Podos, Alcon Lab C.
  • Footnotes
    Support  NIH grant EY01867 and an unrestricted grant from RPB
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4385. doi:
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      D.J. Gagliuso, R. Wang, T.W. Mittag, S.M. Podos; Comparison of the Additive Ocular Hypotensive Effect of Bimatoprost or Travoprost to Latanoprost in Glaucomatous Monkey Eyes and the Effect of Each on Outflow Facility in Normal Monkey Eye . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4385.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To compare the additive ocular hypotensive effect of bimatoprost (B) or travoprost (T) to latanoprost (L) in monkey eyes with laser-induced unilateral glaucoma and the effect on tonographic outflow facility (C) of B, T and L in normal monkey eyes. Methods: Four monkeys with unilateral laser-induced glaucoma were used in each treatment group. Intraocular pressure (IOP) was measured hourly for 6 hours beginning at 9:30 a.m. on day 1 (untreated baseline), days 6 and 7 (single agent therapy), and days 13 and 14 (combination therapy with two drugs). Following a one day baseline measurement, 4 eyes with glaucoma were treated either with one drop of 0.005% L or 0.004% T on days 2 through 7. Both groups received both drops 5 minutes apart on days 8 though 14. A similar experiment was carried out using L and 0.03% B (ARVO 2002). A control experiment used one drop of L for one week and two drops of L 5 minutes apart for the second week. In eight different monkeys without glaucoma, C was measured before and 1 to 2 hours after unilateral application of one drop of B, T or L. Results: The maximum additive reduction in IOP was as follows: L+T (first drug + second drug): 3.0 ± 0.6 (mean ± SEM) mmHg (p<0.05); T+L: 2.0 ± 0.4 mmHg (p<0.05); L+B: 4.8 ± 1.3 mmHg (p<0.05); B+L: 4.3 ± 0.6 mmHg (p<0.05); L+L: 0.3 ± 0.5 mmHg (p>0.60). There was an additional hypotensive response by adding B to L or T to L (p<0.05) but not by adding L to L. The additional reduction of IOP adding B to L was greater (p<0.05) than adding T to L at trough and hour 2. Compared with vehicle-treated contralateral control eyes, C was increased by 33% with B (p<0.005), by 18% with T (p<0.05), and by 18% with L (p>0.10) after single dose application in normal monkey eyes. Conclusions: The intraocular pressure effects of the commercial concentrations of either B or T are additive to a maximum dose of L. Tonographic outflow facility is increased by either B or T.

Keywords: drug toxicity/drug effects • intraocular pressure • pharmacology 
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