May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
A Clinical Study of Cataract in Survivors Exposed to Atomic-Bomb Radiation in Childhood
Author Affiliations & Notes
  • N. Yoshitani
    Ophthalmology & Visual Science, Graduate School of Biomedical Sciences,Hiroshima Univ, Hiroshima-shi, Japan
  • A. Minamoto
    Ophthalmology & Visual Science, Graduate School of Biomedical Sciences,Hiroshima Univ, Hiroshima-shi, Japan
  • H.K. Mishima
    Ophthalmology & Visual Science, Graduate School of Biomedical Sciences,Hiroshima Univ, Hiroshima-shi, Japan
  • H. Taniguchi
    Ophthalmology & Visual Science, Graduate School of Biomedical Sciences,Nagasaki Univ, Nagasaki-shi, Japan
  • T. Kumagami
    Ophthalmology & Visual Science, Graduate School of Biomedical Sciences,Nagasaki Univ, Nagasaki-shi, Japan
  • T. Amemiya
    Ophthalmology & Visual Science, Graduate School of Biomedical Sciences,Nagasaki Univ, Nagasaki-shi, Japan
  • K. Neriishi
    Clinical Studies(Hiroshima), RERF, Hiroshima-shi, Japan
  • E. Nakashima
    Statistics, RERF, Hiroshima-shi, Japan
  • A. Hida
    Clinical Studies(Nagasaki), RERF, Nagasaki-shi, Japan
  • Footnotes
    Commercial Relationships  N. Yoshitani, None; A. Minamoto, None; H.K. Mishima, None; H. Taniguchi, None; T. Kumagami, None; T. Amemiya, None; K. Neriishi, None; E. Nakashima, None; A. Hida, None.
  • Footnotes
    Support  RERF RP 3-00
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4465. doi:
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    • Get Citation

      N. Yoshitani, A. Minamoto, H.K. Mishima, H. Taniguchi, T. Kumagami, T. Amemiya, K. Neriishi, E. Nakashima, A. Hida; A Clinical Study of Cataract in Survivors Exposed to Atomic-Bomb Radiation in Childhood . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4465.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To investigate whether slowly progressive radiation cataracts may occur later in life of atomic-bomb (A-bomb) survivors. Methods: Ophthalmological examinations were performed with Hiroshima and Nagasaki A-bomb survivors, who were younger than 13 years at the time of the bombs, during their routine biennial examinations of Radiation Effects Research Foundation's (RERF) Adult Health Study (AHS) from June 2000 to September 2002. The ophthalmological examination followed a protocol included an interview, visual acuity, refraction, tonometry, and after pupil dilatation slit-lamp lens grading according to Lens Opacity Classification II (LOCS II), slit- and retroillumination photographs of the lens which were stored as digital computer images. Associations between lens opacities and dose of radiation were evaluated by proportional odds regression analysis. Estimated doses were based on the DS86 dosimetry system, which calculates an estimate for the subject's location and is adjusted to reflect shielding information. Results: There were 873 examinees with gradable lens opacity data and radiation dose data. There was no significant relationship between nuclear color (p=0.14) or nuclear opacity (p=0.11) and the dose of radiation. There were significant increases in cortical opacities (p<0.01) and posterior subcapsular opacities (p<0.01) with higher radiation dose. Conclusion: The present study implies the possibility of radiation as the cause of cortical cataract as well as posterior subcapsular cataract in A-bomb survivors.

Keywords: cataract • clinical (human) or epidemiologic studies: pre • radiation damage: light/UV 
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