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H. Shao, Y. Fu, H.J. Kaplan, D. Sun; LTßR-Ig Treatment Blocks Actively Induced, but not Adoptively Transferred, Uveitis in Lewis Rats . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4596.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Treatment of rodents with a lymphotoxin ß receptor fusion protein (LTßR–Ig), which binds to both LT and LIGHT, prevents the development of autoimmune diseases. In this study, we wanted to explore the potential role of LT or LIGHT in the pathogenesis of autoimmune uveitis. Methods: Uveitis was induced in Lewis rats either by immunization with an uveitogenic peptide, R16, derived from the interphotoreceptor retinoid-binding protein (IRBP) or by adoptive transfer of R16-specific T cells. The animals were then treated with LTßR-Ig or HVEM-Ig or control Ig. The incidence and severity of uveitis were observed and T cell activation from treated and control-treated immunized rats was determined. Results: LTßR–Ig treatment completely prevented actively induced uveitis, but not the adoptively transferred disease. LTßR–Ig-treated R16-injected rats had a significantly decreased T cell response to R16 and that HVEM-Ig, a fusion protein that blocks LIGHT also inhibited disease development. Conclusion: LIGHT plays an important role in the induction of uveitis and that LTßR–Ig treatment reduces LIGHT activity.
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