Purchase this article with an account.
A.M. Oboh, H. Lai, F. Weilke, J. Rafaie, A.S. Jun, W.J. Stark, J.D. Gottsch; Correlation of Visual Acuity with Pachymetry in Patients with Fuchs' Endothelial Dystrophy . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4742.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the relationship between pachymetry and visual acuity in patients diagnosed with Fuchs' endothelial dystrophy. Methods: Records of patients with Fuchs' dystrophy seen at the Wilmer Eye Institute between 1995-2002 were retrospectively reviewed. Data on age, sex, visual acuity, pachymetry, intraocular pressure and diagnosis of eye diseases were collected. Patients with cataracts and other ocular pathologies or those who had undergone prior intraocular surgery were excluded from the study. Data analysis was performed using the Generalized estimating equations (GEE) method. Pachymetry was treated as an independent variable, and LogMar as a dependent variable. Results: Records of 102 patients (204 eyes) over a time course of 7 years were abstracted. The female to male ratio was 2.1:1. At baseline, patients aged 20 to 90 years (means±SD: 66.4±13.3). Corneal thickness ranged from 420 to 900 µm and LogMar values ranged from -0.1249 to 1.3010. After the adjustment for age, visit and two eyes of each patient, pachymetry was positively correlated with LogMar; an average of 0.0239 increase in LogMar for every 100 µm increment in pachymetry, (p <0.0001). Further more, the higher corneal thicknesses, defined as pachymetry >600 µm were positively associated with visual acuity worse than 20/40 (LogMar > 0.3010). Also, patients with higher corneal thicknesses were twice as likely to have 20/40 vision or worse (OR and 95% CI: 2.67 and 1.72-4.15). Conclusion: In Fuchs' dystrophy patients, decreasing visual acuity correlates with increasing pachymetry. Larger increases in pachymetry (>100um) were required before substantial decreases in visual acuity were observed, and patients with pachymetry <600um showed relatively minor decreases in visual acuity. These findings may impact on current practice patterns to perform combined corneal transplant and cataract surgery in Fuchs' dystrophy.
This PDF is available to Subscribers Only