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E.D. Donnenfeld, R. Solomon, S. Doshi, H.D. Perry, R.W. Snyder, H.G. Jensen; Prophylaxis of Streptococcus pneumoniae Keratitis with Gatifloxacin in a Rabbit LASIK Model . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4745.
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Purpose: To investigate the efficacy of Gatifloxacin as compared to Ciprofloxacin in preventing Streptococcus pneumoniae keratitis in a rabbit LASIK model. Methods: Twelve Albino rabbits had bilateral lamellar flaps created. Group A (8 eyes) was given Gatifloxacin 0.3%, Group B (8 eyes) was given Ciprofloxacin 0.3% and Group C (8 eyes) served as the control. Group A and B received one drop of antibiotic 20 minutes prior to the lamellar flap, at the conclusion of flap formation, and qid for three days. All corneas were inoculated with 0.1cc of 4 x 105 organisms/mL of Streptococcus pneumoniae immediately following flap formation. On day 3 all corneas were evaluated and cultured. Results: Group A (Gatifloxacin) had no infiltrates and 3 areas of 1 mm central corneal haze. On day 3 one of eight rabbits had positive cultures on. Group B (Ciprofloxacin) had 7 infiltrates including one perforation and 6 of 8 had positive cultures. Group C had 8 corneal infiltrates and all 8 had positive cultures. Conclusions: Gatifloxacin 0.3% is superior to Ciprofloxacin 0.3% for prophylaxis against Streptococcus pneumonaie in a rabbit LASIK model.
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