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R.A. Eiferman; The Post Antibiotic Effect (PAE) of Four Ophthalmic Fluoroquinolones and the Sensitivity of Gram Positive and Gram Negative Bacteria To Moxifloxacin . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4760.
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Purpose: To determine the sensitivity of moxifloxacin, a new fourth generation fluoroquinolone, against gram positive and gram negative bacteria and to determine the post antibiotic effect (PAE) of moxifloxacin, ofloxacin, levofloxacin and ofloxacin against Staphylococcus aureus and Pseudomonas aeruginosa. Methods: A library of ATCC strains were tested for sensitivity to moxifloxacin. Moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin were tested at 4X MIC against Staphylococcus aureus and Pseudomonas aeruginosa. The PAE was determined by measuring the time for a one log increase in number of organisms as compared to control. Results: 90% Staphylococcus, 100% Haemophilus, 100% Streptococcus, 100% Moraxella, 90% Pseudomonas and zero % MRSA were sensitive to moxifloxacin. The PAE of moxifloxacin against Staphylococcus aureus was 2.8 hrs; ofloxacin was 1.5 hrs; levofloxacin was 2.1 hrs; and ciprofloxacin was 1.4 hrs. The PAE of moxifloxacin against Pseudomonas was 2 hrs; ofloxacin was 0.6 hr; levofloxacin was 0.9 hr; and ciprofloxacin was 1.1 hr. Conclusions: Moxifloxacin appears to be a very potent antibiotic with broad spectrum activity against gram positive and gram negative organisms with a longer PAE than the older fluoroquinolones. 100% of Streptococcus, Haemophilus and Moraxella species tested were sensitive to moxifloxacin.
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