May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Pharmacokinetics of Gentamycin in the Rabbit Eye Administered via Iontophoresis
Author Affiliations & Notes
  • J. Pe'er
    Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel
  • F.D. Raiskup
    Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel
  • E. Binstock
    Medical Pharmacy, Hebrew University , School of Pharmacy, Jerusalem, Israel
  • A. Domb
    Medical Pharmacy, Hebrew University , School of Pharmacy, Jerusalem, Israel
  • J. Frucht-Pery
    Medical Pharmacy, Hebrew University , School of Pharmacy, Jerusalem, Israel
  • Footnotes
    Commercial Relationships  J. Pe'er, None; F.D. Raiskup, None; E. Binstock, None; A. Domb, Hadassit P; J. Frucht-Pery, Hadassit P.
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4761. doi:
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    • Get Citation

      J. Pe'er, F.D. Raiskup, E. Binstock, A. Domb, J. Frucht-Pery; Pharmacokinetics of Gentamycin in the Rabbit Eye Administered via Iontophoresis . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4761.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Evaluation of the pharmacokinetic profile of gentamycin administered to the cornea via iontophoresis. Methods: Five groups of 8 rabbits each (one eye /rabbit) underwent general anaesthesia (inj. Ketamine and inj. Xalazine i.m.). Corneal iontophoresis using hydrogel discs containing gentamycin sulfate with current 1mAmp was applied for 1 min. Following sacrifice [immediately after the treatment (group 1), 1 hour (group 2), 2 hours (group 3), 4 hours (group 4) and 8 hours (group 5) post iontophoresis] aqueous humor was aspirated, corneas excised and gentamycin concentrations determined in the samples by TDx analysis. . Results:Concentrations of gentamycin in cornea (µg/gr): group 1(363.1±127.3); group 2 (122.1±47,1); group 3 (138.7±119.6); group 4 (47.8±19.4); group 5 (24.9± 6.1). Concentrations of gentamycin in aqueous humor (µg/ml): group 1 (3.0±3.0); group 2 (9.4± 1.5); group 3 (29.4±17.4); group 4 (13.7±10.0); group 5 (0.9± 0.2). The highest concentrations of gentamycin in cornea were found immediately after the iontophoresis and gradually declined up to the period 8 hours after the treatment. Levels of the drug 8 hours post iontophoresis were almost identical with the levels in the group (previous study) where gentamycin was administered topically by drops, every 5 min for 1 hour. The highest concentration of the drug in the aqueous humor was detected 2 hours after the iontophoresis. Conclusions:Iontophoresis using hydrogel discs immersed in gentamycin sulfate may deliver therapeutic concentrations of the drug into the cornea and anterior chamber by single administration.

Keywords: pharmacology • antibiotics/antifungals/antiparasitics • cornea: basic science 
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