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A. Kojima, K. Ohno-matui, S. Teramukai, Y. Ishihara, T. Yoshida, T. Tokoro, M. Mochizuki; Influencing Factors on the Enlargement of Chorioretinal Atrophy around Myopic Choroidal Neovascularization . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4792.
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Purpose:The development of chorioretinal atrophy (CRA) around choroidal neovascularization (CNV) is a major cause of long-term visual decrease in eyes with myopic CNV. In the present study, we investigated the factors that influence enlargement of CRA in a large series of highly myopic patients.Methods:A consecutive series of 81 eyes (73 patients) with myopic CNV were retrospectively included in the study. The size of CRA 3 years after CNV onset was measured using color fundus photography and image analysis software (Image scan, Bata 4.0.2). Factors that correlate with the size of CRA 3 years after CNV onset were analyzed using a backward-elimination multiple linear regression. The factors examined were patients’ age at onset, visual acuity (logMAR) at the onset of CNV, axial length, the existence of lacquer cracks, size of CNV, and the maximum range of subretinal bleeding during follow-up.Results:A backward-elimination multiple linear regression analysis demonstrated that age at onset and the existence of lacquer cracks were significant factors for the enlargement of CRA in all the patients examined. Patients were divided into two groups according to their age at onset (ÅÖ40 years and >40 years), and analyzed using the same methods for each group. In the younger group, CRA size significantly correlated with the existence of lacquer cracks and the size of CNV. On the other hand, in the older group, age at onset was the only significant factor for CRA enlargement.Conclusions:CRA enlargement significantly correlated with the existence of lacquer cracks and the size of CNV in the younger group. In the older group, however, only advanced age was an unfavorable prognostic factor. These findings might facilitate diagnosis of those cases that will result in severe visual loss and development of treatments that will help maintain satisfactory vision.
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