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H.G. Yu, K.S. Choi, J. Heo, H. Chung, J.Y. Oh; The Effect of Ginkgo biloba in Experimental Ischemic Retina After Photodynamic Injury . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4922.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To examine the effect of Ginkgo biloba ( in retinal ischemia model by retinal vein occlusion after photodynamic injury. Methods: Photothrombosis was produced in central retinal vein by the combination of intravenous injection of rose bengal (photosensitive dye). Ginkgo biloba (20, 100mg/kg) was injected orally with carboxymethylcellulose once a daily for 7days before photodynamic injury and 2 weeks after. Eyes were examined at intervals during the subsequent day with ophthalmoscopy, fluorescein angiography, photograpy. Rats were killed 2weeks after injury and ischemic retinal cell death was detected with TUNEL stain and histopathologic feature. Results: Retinal detachments developed 1 or 2 day after laser treatment, and reperfusion of occluded vein was noted 5 or 7 days after injury. New vessels was first noted 12days after injury. In no treatment group, severe disarrangement of retina and new vessel were more developed than treated groups. Conclusions: Ginkgo biloba provide protection to the retina from ischemia.
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