May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Effect of Systemic Hypertension on Foveolar Choroidal Hemodynamics
Author Affiliations & Notes
  • R.M. Niknam
    Ophthalmology, Univ Penn-Scheie Eye Inst, Philadelphia, PA, United States
  • L.S. Schocket
    Ophthalmology, Univ Penn-Scheie Eye Inst, Philadelphia, PA, United States
  • J.C. DuPont
    Ophthalmology, Univ Penn-Scheie Eye Inst, Philadelphia, PA, United States
  • T.I. Metelitsina
    Ophthalmology, Univ Penn-Scheie Eye Inst, Philadelphia, PA, United States
  • J.E. Grunwald
    Ophthalmology, Univ Penn-Scheie Eye Inst, Philadelphia, PA, United States
  • Footnotes
    Commercial Relationships  R.M. Niknam, None; L.S. Schocket, None; J.C. DuPont, None; T.I. Metelitsina, None; J.E. Grunwald, None.
  • Footnotes
    Support  NIH grant EY 12769, RPB and the Vivian S. Lasko Research Fund
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 4928. doi:
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      R.M. Niknam, L.S. Schocket, J.C. DuPont, T.I. Metelitsina, J.E. Grunwald; Effect of Systemic Hypertension on Foveolar Choroidal Hemodynamics . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4928.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: Systemic hypertension (SH) is a known risk factor for age-related macular degeneration and diabetic retinopathy. We assessed the effect of systemic hypertension on the choroidal circulation. Methods: Laser Doppler flowmetry (Oculix) was used to determine relative choroidal blood velocity (Chvel), volume (Chvol), and flow (Chflow) in the center of the fovea. After pupillary dilatation was achieved, hemodynamic parameters were measured by asking study participants to fixate on a probing laser beam. Measurements were obtained in one eye of thirty subjects. Fifteen subjects had SH and fifteen were age-matched healthy controls. Twelve of the 15 subjects with SH were on antihypertensive medications and three were not receiving medication because they had been recently diagnosed. Average known duration of SH was 11±6 years (mean±SD). All subjects included had no clinical evidence of progressive intraocular disease. Following blood flow measurements heart rate and blood pressure were measured. Results are shown in arbitrary units (AU). Results: We found no significant differences in Chvel, Chvol, and Chflow between subjects with systemic hypertension and controls in spite of the fact that mean blood pressure was 12.4% higher in the subjects with SH (t-test, p=0.007). When all the subjects were analyzed together, a significant inverse correlation between Chflow and age was found Chflow (r=-0.388, p=0.034) confirming our previous findings (Arch Ophthalmol 1998;116:150). Because we did not detect any significant effect of hypertension on Chflow we estimated that we have an 84% power to detect a 35% difference in Chflow between the two groups. Conclusion: SH does not seem to have a large effect on the choroidal circulation in hypertensive subjects that are controlled by antihypertensive therapy or in subjects with a recent diagnosis. Further studies are needed to clarify if SH has an effect on the choroidal circulation in patients with ocular disease.  

Keywords: blood supply • choroid • age-related macular degeneration 
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