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P.J. Maris, V.C. Greenstein, J.G. Odel.; Retinal and Visual Function Assessment in Albinotic Nevus . Invest. Ophthalmol. Vis. Sci. 2003;44(13):4976.
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Purpose: To investigate retinal and visual function in a patient with an albinotic nevus of the retinal pigment epithelium (RPE). Albinotic nevus, described by Gass, has been assumed to involve only the RPE but controversy exists as to whether it causes visual field defects, indicating retinal involvement.  Methods: A 10 year-old patient with a two-disc-diameter albinotic nevus located approximately 12 degrees temporal to the fovea was examined by fundus photography, fluorescein angiography, Goldmann kinetic perimetry, Humphrey 24-2 visual fields and multifocal ERGs. The mfERG stimulus consisted of 103 scaled hexagons and the display subtended 50 degrees in diameter. Fixation was monitored with a refractor/camera. Results: Best corrected visual acuity in the affected eye was 20/20. Fundus examination and fluorescein angiography were both consistent with an albinotic nevus. A small visual field defect was demonstrated on both Goldmann perimetry (I/2e test object) and on Humphrey 24-2 visual field testing (significant at the 0.5% level for pattern deviation) approximately 12 degrees nasal to fixation. The remaining visual field of the involved eye was normal. The multifocal ERG revealed a decreased response amplitude in the corresponding area and increased implicit time. Conclusion: The results indicate that albinotic nevus can be accompanied by visual field and outer retinal deficits. The multifocal ERG and perimetry aid in our understanding of this condition. 1. Gass and Roseman (1992) Arch Opthal
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