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J.L. Rosales, P.P. Bonomo De Oluveira, P.P. Morales B, C. Campos, A. Belfort, L.J. Florez Ovalles; Transpupillary Thermotherapy in Patients with Exudative Age Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5018.
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Purpose: To assess the effectiveness of transpupillary thermotherapy for treatment of classic and occult choroidal neovascularization in patients with ARMD Methods: In a prospective study, 12 patients (12 eyes) with CNV secondary to ARMD, were studied from January 2001 to January 2002. This 12 eyes with angiographically defined CNV were treated with diode laser (IRIDIS, QUANTEL MEDICAL, FRANCE, 810nm). Laser beam sizes ranged between 0.5 and 3.0 mm and power settings between 300-800 mW. Treatment was given in the CNV area for 60 seconds, the end point being no visible change or a slight greying of the retina. Outcome was assessed with Snellen visual acuity, clinical examination and angiographically with fluorescein. Results: Six patients with predominantly classic CNV and six patients with predominantly occult CNV were followed up for one year. Mean change in vision for classic membrane was -0.75 (SD 1.75) and occult membranes were -0.66 snellen lines (p>0.05). The predominantly classic membranes were closed in 67% of eyes, remained persistent in 33%; no recurrences. Predominantly occult membranes were closed in 83% eyes, remained persistent in 17% and were recurrent in 20%. Conclusions: The TTT is a potencial treatment for patients with exudative ARMD. It is able to close CNV while maintaining visual function in patients with classic and occult form disease. Others trials of TTT are needed to compare this intervention with other treatment modalities.
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