May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Combined Photodynamic Therapy (PDT) with Subtenon Triamcinolone Acetonide for CNV in AMD and Non-AMD Patients
Author Affiliations & Notes
  • E.G. Lucena
    Retina, Visoclinic, Rio de Janeiro, Brazil
  • M.D. Rachid
    Clinica de Olhos do Rio, Rio de Janeiro, Brazil
  • M.L. Aiube
    Clinica de Olhos do Rio, Rio de Janeiro, Brazil
  • A.S. Lucena
    Glaucoma, Visoclinic, Rio de Janeiro, Brazil
  • J. Goncalves
    Ophthalmology, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil
  • Footnotes
    Commercial Relationships  E.G. Lucena, None; M.D. Rachid, None; M.L. Aiube, None; A.S. Lucena, None; J. Goncalves, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 5041. doi:
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      E.G. Lucena, M.D. Rachid, M.L. Aiube, A.S. Lucena, J. Goncalves; Combined Photodynamic Therapy (PDT) with Subtenon Triamcinolone Acetonide for CNV in AMD and Non-AMD Patients . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5041.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: We report the short term visual acuity and fluorescein angiographic effects of a single photodynamic therapy treatment combined with subtenon triamcinolone acetonide (TA) injection in AMD and non-AMD patients with choroidal neovascular membranes in a pilot study. Methods: The non-randomized prospective clinical interventional study included 8 eyes of 8 patients having predominantly classic subfoveal choroidal neovascular membranes divided in 2 groups – 5 AMD patients and 3 non-AMD patients. Standardized visual acuity, anterior segment biomicroscopy, IOP measure, fundus examination and fluorescein angiography were recorded at baseline and during follow up (range 4 to 12 months). Five days after treatment with photodynamic therapy using verteporfin (6 mg/m2) in a standard fashion, all patients received a 40 mg subtenon injection of triamcinolone acetonide. Results: The mean visual acuity improved 1 line (range 5 to –2 lines) in the AMD group and 4.3 lines (range 6 to 2 lines) in the Non-AMD group from baseline to the follow up at week 12. No leakage in the primary lesion was noticed in 2 eyes of the AMD group and in all eyes in the non-AMD subgroup. Secondary elevation of the IOP was observed in 2 patients 2 weeks after the TA injection were prescribed anti-glaucoma medications. No major complications were observed. Conclusion: These preliminary data suggest this combined approach for treatment of choroidal neovascular membranes may have a remarkable benefit in the Non AMD group of patients providing a short term improvement of visual acuity after a single photodynamic therapy treatment and some benefit in the AMD group.

Keywords: choroid: neovascularization • age-related macular degeneration • photodynamic therapy 
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