Purchase this article with an account.
S. Kim, S. Kim, H.G. Yu, Y.S. Yu, H. Chung, B. Chang, S. Jung; Recording of Cortical Response to the Electrical Stimulation of the Optic Nerve in Rats Using Depth Electrode . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5057.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: The cortical activity elicited by electrical stimulation of the optic pathway has been recorded by surface evoked potentials. In this study, Single unit responses of the primary visual (V1) cortical neurons to the electrical stimulation of the optic nerve were characterized in anesthetized rats to establish the animal model for analysis of the signal processing of visual system and for estimating the feasibility of the visual prosthesis. Methods: Simultaneous multi-single unit recordings of V1 (layer 4) cortical area were performed during electrical stimulation of optic nerve. Multi-channel tungsten microelectrode (tip diameter 2µm) was used to record neural signals in Sprague-Dawley rats (250~350g). At first, the cortical neurons responding to the 2 Hz flash light stimuli were identified. Thereafter, current stimuli were applied using hook-shaped electrode and the spontaneous activities and evoked responses were recorded. Results: The neuronal responses to electricity were biphasic and were similar to those by flash light stimulation of the eye. Initial spike group of short latency (5-20ms) and the other spike group with delayed latency (200-300ms) were found. Conclusions: This is the first report to record the cortical neuronal responses to the electrical stimulation of the visual pathway. The reported technique permits analysis of cortical functions and will be a good way to monitor the proper functioning of the visual prosthesis.
This PDF is available to Subscribers Only