May 2003
Volume 44, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2003
Electrically-evoked Potentials after Subretinal Implantation of the Microelectrode Array in Rabbits
Author Affiliations & Notes
  • Y.S. Yu
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center (SAEC), Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • S. Kim
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center (SAEC), Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • S. Kim
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center (SAEC), Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • J. Seo
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center (SAEC), Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • H.G. Yu
    Department of Ophthalmology, Seoul National University College of Medicine and Seoul Artificial Eye Center (SAEC), Seoul National University Hospital Clinical Research Institute, Seoul, Republic of Korea
  • S. Kim
    Nano Bioelectronics and Systems Engineering Research Center (NBS-ERC), School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • H. Chung
    Nano Bioelectronics and Systems Engineering Research Center (NBS-ERC), School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  Y.S. Yu, None; S. Kim, None; S. Kim, None; J. Seo, None; H.G. Yu, None; S. Kim, None; H. Chung, None.
Investigative Ophthalmology & Visual Science May 2003, Vol.44, 5070. doi:
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      Y.S. Yu, S. Kim, S. Kim, J. Seo, H.G. Yu, S. Kim, H. Chung; Electrically-evoked Potentials after Subretinal Implantation of the Microelectrode Array in Rabbits . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5070.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To test the feasibility of the retinal prosthesis, we recorded electrically-evoked cortical potentials (EEP) using a micro-fabricated matrix electrode array, which was made by NBS-ERC. Methods: After performing the visual evoked potential (VEP), a 5x5 polyimide electrode array was placed into the subretinal space of the rabbit eye. Cutaneous Ag/AgCL patch electrodes of VEP were also used to record EEP. EEPs were recorded at each stimulation of the array and compared with the VEP results. Results: EEP recordings were elicited by the bipolar pulse stimulation with 1ms duration and 1~5mA current. The shape of the waveform of evoked responses was biphasic pattern with two peaks like VEP, but the amplitude was smaller and latency was shorter than that of VEP. Stimulation of different site of the array did not show different results. Conclusions: Focal electrical stimulation of the retina might be a reasonable approach to provide light to blind patients with outer retinal disease and the use of the EEP response is a good way to monitor the proper functioning of the retinal implant.

Keywords: electrophysiology: non-clinical • neuro-ophthalmology: cortical function/rehabil • visual cortex 
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