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H.G. Sachs, C. Framme, F. Gekeler, T. Schanze, W. Nisch, U. Brunner, E. Zrenner, V.P. Gabel; Surgical Procedure for the Implantation of Foil Strip Stimulators for Repentable Stimulation in the Subretinal Space of Cats for the Purpose of Stimulation Parameter Determination in Visual Prosthesis Development . Invest. Ophthalmol. Vis. Sci. 2003;44(13):5073.
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Purpose: The determination of electric stimulus parameters is crucial for the development and tolerance of a chronic subretinal visual prosthesis. To achieve this data foil bound stimulators with extraocular contact structures were implanted in the subretinal space of cats. Methods: Standard pars plana vitrectomy was modified for the demands of the cats eye. 2x44 mm foil strips with multiple electrodes on the subretinal side and a contact plate (8x8 mm) on the subconjunctival side were implanted in 6 cat eyes to carry out electric stimulation from the subretinal space in the follow up period of 3 month. For subretinal stimulation the conjunctiva was reopened and the contact plate connected to the stimulation device. Cortical recordings were performed. Results: Subretinal stimulation foils with transscleral connection and subconjunctival contact structures were safely implantable in cats eyes for repeatable stimulation of the retina out of the subretinal space. Repeated reopening of the conjunctiva to contact the foil was tolerated well. The permanent transscleral entry of the foil in the pars plana region of the cat was stable and did not lead to adverse events. The position of the subretinal foil was stable under silicon oil in the follow up period. Conclusions: With the permanent transscleral placed stimulation foil a variety of variable stimulation experiments is possible. Repeatable experiments over a period of months can be achieved. The tolerance of the permanent transscleral entry and the connection into the subretinal space from the subconjunctival region opens the way to design complex and bigger subretinal prosthetic structures. Grant: BMBF (German Ministry of Reseach) 01 KP 0012
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