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Y Takano, K Fukagawa, N Asano-Kato, N Okada, E Akagawa, K Tsubota, H Fujishima; Neutrophil Chemoattractants in the Tears of Patients With Severe Allergic Conjunctival Diseases . Invest. Ophthalmol. Vis. Sci. 2002;43(13):112.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:Many inflammatory cells including neutrophils are observed in the tears of patients with severe allergic conjunctival diseases such as vernal keratoconjunctivitis(VKC) and atopic keratoconjunctivitis(AKC). Neutrophils are thought to migrate into tears by the action of chemoattractants present in the tear fluid. In this study, we examined the concentrations of neutrophil chemoattractants, IL-8 and LTB4 in the tears of normal patients and patients with severe allergies. Methods:Twelve patients with VKC or AKC and 8 normal non-allergic controls were enrolled. Tear fluid was collected by the capillary method and concentrations were measured by ELISA. Results:IL-8 concentrations of patients with corneal lesions were significantly higher than control patients. LTB4 concentrations in patients with corneal erosions were significantly higher than control patients. Conclusion:IL-8 and LTB4 were observed in higher concentrations in patients with severe allergic conjunctival diseases. These findings suggest that IL-8 and LTB4 play an important role in the chemotaxis of neutrophils and the pathogenesis of such diseases.
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