December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Neutrophil Chemoattractants in the Tears of Patients With Severe Allergic Conjunctival Diseases
Author Affiliations & Notes
  • Y Takano
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • K Fukagawa
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • N Asano-Kato
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • N Okada
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • E Akagawa
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • K Tsubota
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • H Fujishima
    Ophthalmology Tokyo Dental College/Ichikawa Gen Hosp Ichikawa Japan
  • Footnotes
    Commercial Relationships   Y. Takano, None; K. Fukagawa, None; N. Asano-Kato, None; N. Okada, None; E. Akagawa, None; K. Tsubota, None; H. Fujishima, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 112. doi:
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    • Get Citation

      Y Takano, K Fukagawa, N Asano-Kato, N Okada, E Akagawa, K Tsubota, H Fujishima; Neutrophil Chemoattractants in the Tears of Patients With Severe Allergic Conjunctival Diseases . Invest. Ophthalmol. Vis. Sci. 2002;43(13):112.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:Many inflammatory cells including neutrophils are observed in the tears of patients with severe allergic conjunctival diseases such as vernal keratoconjunctivitis(VKC) and atopic keratoconjunctivitis(AKC). Neutrophils are thought to migrate into tears by the action of chemoattractants present in the tear fluid. In this study, we examined the concentrations of neutrophil chemoattractants, IL-8 and LTB4 in the tears of normal patients and patients with severe allergies. Methods:Twelve patients with VKC or AKC and 8 normal non-allergic controls were enrolled. Tear fluid was collected by the capillary method and concentrations were measured by ELISA. Results:IL-8 concentrations of patients with corneal lesions were significantly higher than control patients. LTB4 concentrations in patients with corneal erosions were significantly higher than control patients. Conclusion:IL-8 and LTB4 were observed in higher concentrations in patients with severe allergic conjunctival diseases. These findings suggest that IL-8 and LTB4 play an important role in the chemotaxis of neutrophils and the pathogenesis of such diseases.

Keywords: 366 conjunctivitis • 380 cytokines/chemokines • 376 cornea: tears/tear film/dry eye 
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