December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Alkali Injury Causes Inflammatory Response in the Retina, Leading to the Retinal Damage
Author Affiliations & Notes
  • S Den
    Ophthalmology Osaka Medical College Osaka Japan
  • C Sotozono
    Ophthalmology Kyoto Pref Univ of Medicine Kyoto Japan
  • S Kinoshita
    Ophthalmology Kyoto Pref Univ of Medicine Kyoto Japan
  • H Oku
    Ophthalmology Osaka Medical College Osaka Japan
  • T Ikeda
    Ophthalmology Osaka Medical College Osaka Japan
  • Footnotes
    Commercial Relationships   S. Den, None; C. Sotozono, None; S. Kinoshita, None; H. Oku, None; T. Ikeda, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 27. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      S Den, C Sotozono, S Kinoshita, H Oku, T Ikeda; Alkali Injury Causes Inflammatory Response in the Retina, Leading to the Retinal Damage . Invest. Ophthalmol. Vis. Sci. 2002;43(13):27.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose:In sever alkali injury, alkali solution penetrates to the intraocular tissues and causes extensive ocular damage. To know retinal damage, we investigated changes in retinal function, structure and inflammatory cytokine expression after alkali injury. Methods:Central corneal alkali injuries were produced by placing filter paper discs wetted with 1N NaOH on 6 Wistar rat corneas for 1 min. Six uninjured eyes were served as controls. Changes in retinal function were evaluated 1, 2, 4 and 8 weeks after injury, using electroretinogram (ERG). Histological changes were examined 4 and 8 weeks after injury. Also, interleukin (IL)-1ß, -6 and -8 in the alkali-injured retinas were quantified using ELISA systems. Results:The amplitudes of a- and b-wave were significantly reduced 8 weeks after injury in alkali-injured eyes. Histological examination revealed massive retinal destruction and cell infiltration. IL-1ß, -6 and -8 were elevated after alkali injury which reduced to the control levels by 7 days. Conclusion: The results suggest that alkali injury to the cornea may cause inflammatory response in the retina, leading to retinal damage. For better visual prognosis after alkali injury, it may be necessary to suppress sufficiently these inflammatory reactions.

Keywords: 370 cornea: basic science • 437 inflammation • 396 electroretinography: non-clinical 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×