December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Color Doppler Imaging And Vascular Impairment In Normal Subjects
Author Affiliations & Notes
  • MG UvaItalian Ocular Blood Flow Study Group
    Institute of Ophthalmology Catania University Catania Italy
  • Footnotes
    Commercial Relationships   M.G. Uva, None.
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 303. doi:
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      MG UvaItalian Ocular Blood Flow Study Group; Color Doppler Imaging And Vascular Impairment In Normal Subjects . Invest. Ophthalmol. Vis. Sci. 2002;43(13):303.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To assess if Color Doppler Imaging (CDI) parameters of posterior orbital vessels may vary as a function of vascular impairment in normal individuals. Methods:A multi-center, cross-sectional investigation was performed in 7 centers in Italy. Eligibility criteria were as follows: (a) normal optic disc, (b) normal computer-assisted perimetry (24/2 HFA), (c) IOP < 22 mmHg, (d) no history of ocular disease and previous ocular surgery. CDI of ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (SPCA) was performed by means of a standard 7.5 MHz probe on patients in supine position. Blood pressure and heart rate were monitored through the examination. The following information were collected and arbitrarily ranked to obtain a index of vascular impairment (IVI): age, sex, cigarette smoking, myopia, diabetes, number of cardiovascular medication (including anti-coagulant) currently in use, history of migraine, history of "amaurosis fugax", documented history of systemic vasculitis, "beta" peripapillary atrophy, disc hemorrhages, diastolic blood pressure. The index could range between 2 and 54.5. Linear regression analysis was adopted to evaluate the presence of any association between the resistivity index (RI), as obtained by CDI, and the IVI. Results:152 subjects with a mean age of 61 ± 8.2 yrs were recruited. CDI parameters were the followings: (a) OA RI = 0.72+0.06 (right eye) 0.72+0.06 (left eye); (b) CRA RI = 0.68+0.1 (right eye), 0.70+0.11 (left eye); (c) SPCA RI = 0.65+0.09 (right eye) , 0.64+0.10 (left eye). The IVI ranged from 3 to 24 (median = 8.7). A significant linear association between the IVI and the following arteries was detected: (a) CRA RI (right eye), r2=0.35, p <0.0000, (b) SPCA RI (right eye), r2=0.28, p<0.0000. Similar figures were detected in the fellow eye. No association was found between the RI of OA and the IVI. Conclusion:In normal subjects, retrobulbar circulation, as assessed by CDI, was linearly associated to an index of ocular and systemic vascular impairment. A proper evaluation of a series of ocular and systemic vascular parameters should be taken into account when assessing blood flow velocity with CDI.

Keywords: 499 optic flow • 331 blood supply • 355 clinical (human) or epidemiologic studies: risk factor assessment 
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