December 2002
Volume 43, Issue 13
Free
ARVO Annual Meeting Abstract  |   December 2002
Correlation between Finger Blood Flow and Changes in Ocular Blood Flow following Therapeutic Intraocular Pressure Reduction in Glaucoma Patients
Author Affiliations & Notes
  • AS Hafez
    Department of Ophthalmology and Guy-Bernier Research Center Maisonneuve-Rosemont Hospital University of Montreal Montreal PQ Canada
  • RL G Bizzarro
    Department of Ophthalmology and Guy-Bernier Research Center Maisonneuve-Rosemont Hospital University of Montreal Montreal PQ Canada
  • MR Lesk
    Department of Ophthalmology and Guy-Bernier Research Center Maisonneuve-Rosemont Hospital University of Montreal Montreal PQ Canada
  • Footnotes
    Commercial Relationships   A.S. Hafez, None; R.L.G. Bizzarro, None; M.R. Lesk, None. Grant Identification: Glaucoma Research Society of Canada, FRSQ, Merck-Frosst Canada
Investigative Ophthalmology & Visual Science December 2002, Vol.43, 313. doi:
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      AS Hafez, RL G Bizzarro, MR Lesk; Correlation between Finger Blood Flow and Changes in Ocular Blood Flow following Therapeutic Intraocular Pressure Reduction in Glaucoma Patients . Invest. Ophthalmol. Vis. Sci. 2002;43(13):313.

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Abstract

Abstract: : Purpose: To correlate between finger blood flow and changes in optic nerve head (ONH) and peripapillary retinal blood flow following therapeutic intraocular pressure (IOP) reduction in open angle glaucoma (OAG) and ocular hypertension (OHT). Methods: OAG (N=20) and OHT (N=20) patients with clinical indication for therapeutic IOP reduction were prospectively enrolled. All patients had a minimum of 4 weeks follow up. Ocular blood flow measurements were obtained by SLDF full-field perfusion analysis using Heidelberg Retina Flowmeter images. Finger blood flow was measured using the Transonic laser Doppler Flowmeter. Finger blood flow was measured at baseline, after immersion in warm water (40°C) for 2 minutes (Flow Max), and after immersion in cold water (4°C) for 10 seconds Statistical evaluations were performed using Pearson’s correlation. Results: The OAG group had a mean IOP reduction of 37% after treatment. A significant negative correlation existed between Flow Max and changes in neuroretinal rim blood flow (r=-0.681, p=0.003), changes in temporal peripapillary retinal flow (r=-0.514, p=0.035) and changes in nasal peripapillary retinal flow (r=-0.552, p=0.022). The OHT group had a mean IOP reduction of 33% after treatment. In contrast to the OAG group, no correlation was found between Flow Max and rim blood flow changes (r=0.144, p=0.556) while a positive correlation was established with temporal peripapillary retinal flow change (r=0.478, p=0.039) and nasal peripapillary retinal flow (r=0.544, p=0.016). There was no correlation between ocular blood flow changes and finger blood flow after cold exposure, or with the vasospasticity index in either group. Conclusion: OAG patients had a significant negative correlation between changes in blood flow in the neuroretinal rim of the ONH and maximum finger Doppler flow. These results may indicate that OAG patients with the most severe vasospastic or atherosclerotic disease show the greatest improvements in neuroretinal rim blood flow following IOP reduction. OHT patients did not demonstrate this correlation.

Keywords: 499 optic flow • 615 vascular occlusion/vascular occlusive disease • 444 intraocular pressure 
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