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LE Kagemann, A Harris, AB Yee, AL Coleman, LJ McCranor, RJ Toft, B Siesky, S Shah, M Zalish; The Clinical Importance of Ocular Perfusion Pressure Calculation With Systemic Medication . Invest. Ophthalmol. Vis. Sci. 2002;43(13):331.
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Purpose:To evaluate the influence of altered blood pressure (BP), heart rate, and intraocular pressure (IOP) on ocular perfusion pressure (PP) with a systemic alpha adrenergic antagonist. Methods:Blood pressure, heart rate, and IOP OU of fifteen normal subjects, (twelve male and three female, with a mean age of 27.3 8.88 years), were taken before and two hours after 60 mg PO nicergoline. Baseline and post-drug measurements were compared by paired Wilcoxin ranked sum test. Linear regression was used to compare percent change of each parameter with PP ( PP = 2/3 of MAP- IOP). Results:There was no significant change in blood pressure or heart rate as compared to baseline measurements. IOP was significantly decreased (p = 0.003 OD and 0.0191 OS). The percent change in PP was significantly correlated with change in systolic blood pressure (p = 0.0002, r2 = 0.736), diastolic blood pressure (p < 0.0001, r2 = 0.857), and heart rate (p = 0.0229, r2= 0.388). There was no significant correlation with PP and IOP. Conclusion:Ocular perfusion pressure is calculated from blood pressure and IOP, however changes in PP may not correlate with measured changes in median IOP, despite significant changes in IOP. Calculating PP is helpful when evaluating the effect of systemic and ocular drugs, specifically those that may affect blood pressure, IOP, or both.
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