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YM Catoira, A Harris, R Rachmiel, B Kaplan, E Rechtman, R Migliardi, M Zalish; Estrogen-Replacement Therapy: the Effect of Raloxifene on Retrobulbar Hemodynamics . Invest. Ophthalmol. Vis. Sci. 2002;43(13):333.
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Purpose: Estrogen-replacement therapy ( ERT ) causes vasodilation and increased blood flow in cerebral vasculature and major peripheral arteries. ERT may enhance ocular circulation by reducing vascular resistance. This study examined the effect of raloxifene(a selective estrogen receptor modulator), an ERT, on retrobulbar hemodynamics in postmenopausal women. Methods: Flow measurements of 30 postmenopausal women receiving 150 mg raloxifene daily were compared to measurements of 29 age-matched postmenopausal women receiving no treatment. Color Doppler imaging (CDI) measured peak systolic (PSV) and end diastolic (EDV) velocities in the ophthalmic (OA) and central retinal arteries (CRA) and the resistive index (RI) (RI = PSV - EDV / PSV). The flow velocity data from the two groups was compared using student's unpaired t-tests. A p value ≤ 0.05 was considered significant. Results: All measured flow velocities were significantly higher in the drug-treated women than the non-treated women (pAll measured flow velocities were significantly higher in the drug-treated women than the non-treated women (p≤0.05) Conclusion: Estrogen-replacement therapy with raloxifene appears to reduce vascular resistance downstream from the OA. This ocular hemodynamic effect may help explain previous reports of a lower prevalence of glaucoma in postmenopausal women receiving ERT compared to postmenopausal women with no treatment.
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