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A Liekfeld, C Hartmann, C Kojetinsky; Different Multifocal Intraocular Lenses - Effect on Lens Epithelial Cells In Vitro on Human Capsular Bags . Invest. Ophthalmol. Vis. Sci. 2002;43(13):415.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the effect of the posterior surface structure in different multifocal intraocular lenses (MIOL) on lens epithelial cells (LEC) in vitro on human capsular bags. Methods: Sham cataract surgery, including anterior capsulorhexis, nucleus hydroexpression, and aspiration of lens fibers, was performed on 18 donor eyes (9 pairs) after removal of the cornea. In each pair one eye had a refractive PMMA MIOL (PA154N, Allergan), the other eye had a diffractive PMMA MIOL (811E, Pharmacia)implanted. Both MIOLs are single-piece-lenses with round edges, but differently structured posterior surfaces. The capsular bag, including the MIOL was dissected free, pinned flat on a culture dish, covered with medium and incubated. It was documented how long it lasted until the posterior capsule was totally covered by a confluent monolayer of LEC. Follow-up time was two months. Results: Posterior capsule was totally covered by a confluent monolayer of LEC on average at day 16,3 (+/- 3,2) in the capsular bags with a refractive MIOL, and at day 16,4 (+/- 4,2) with a diffractive MIOL. In two pairs there was no LEC monolayer within the follow-up period. The difference is not statistically significant. Conclusion: Although the two compared MIOL models have differently structured posterior surfaces, we could not observe different kind of LEC growing on the posterior capsule in this capsular bag model. This also correlates with first clinical observations. So in terms of choosing one of the two special MIOL designs for implantation after cataract removal a difference in secondary cataract might not be of any concern.
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