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C Abela-Formanek, M Amon, J Schauersberger, G Schild, AJ Kruger; Uveal and Capsular Biocompatibility After Implantation of Hydrophilic-acrylic, Hydrophobic-acrylic and Silicone Intraocular Lenses in Eyes with Pseudoexfoliation Syndrome . Invest. Ophthalmol. Vis. Sci. 2002;43(13):423.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: The purpose of this study was to investigate the biocompatibility of 3 different foldable intraocular lenses (IOL) in eyes with pseudoexfoliation syndrome (PEX) and cataract. Methods: <78 PEX- and 78 control eyes were prospectively, randomized for cataract surgery. The patients received a hydrophilic-acrylic (Hydroview® Bausch & Lomb), a hydrophobic-acrylic (Acrysof® MA60MB Alcon) or a silicone (CeeOn 911® Pharmacia) IOL. Cataract surgery, and follow-up was standardized. Postoperative evaluation was performed 1, 3, and 7 days, 1, 3, 6 and 12 months after surgery. Flare was assessed with a laser-flare-cell meter KOWA FC 1000. Cellular reaction was evaluated by specular microscopy, capsular reaction by biomicroscopy. Results: Preoperative flare was significantly higher in PEX eyes as compared to the control group. After 1 year, flare was comparable in both the PEX and control groups. Flare between the IOLs in the PEX group was comparable. After the immediate high postoperative, small round cell reaction on all IOLs, there was a decrease in all 3 IOL groups; the reaction was slightly stronger in the PEX eyes. Although the CeeOn 911 had a higher mean grade of small cells, there was no statistically significant difference between the 3 IOL types 1 year after surgery in the PEX and control groups. Foreign-body giant cells (FBGCs) increased 1 month after surgery. Acrysof had the highest number of FBGCs as compared to the other IOL types. The PEX Hydroview IOLs showed less LEC outgrowth when compared to the control Hydroview group. PEX eyes with Acrysof and CeeOn 911 IOLs had more fibrosis of the anterior capsular rim and of the anterior capsule than the control eyes. There were no clinically significant IOL decentrations. Posterior capsule opacification (PCO) was more severe in the PEX eyes. The Hydroview had more PCO than the Acrysof and the CeeOn 911 in the PEX and control eyes. There was no significant difference between the Acrysof and CeeOn 911. Conclusion: Phacoemulsification and implantation of foldable IOLs made of hydrophilic-acrylic, hydrophobic-acrylic and new generation silicone show a good outcome after cataract surgery.
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