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SK Pandey, L Werner, DJ Apple, AM Izak, RH Trivedi, SD McLeod; Evaluation Of An Accommodative Intraocular Lens In Human And Rabbit Eyes . Invest. Ophthalmol. Vis. Sci. 2002;43(13):444.
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Purpose:To evaluate the insertion, sizing and fitting of a new one-piece silicone accommodative intraocular lens (IOL) in postmortem human eyes and rabbit eyes This lens is designed to work in concert with the capsular bag, according to the traditional Helmoholtz theory of accommodation. Methods:The insertion, sizing and fitting of the lens within the capsular bag, as well as the capsular bag distortion produced during lens insertion and fixation were evaluated by using 4 different models: 1) Two postmortem human eyes were prepared as per Miyake-Apple posterior video technique, and phacoemulsification was performed. 2) Two postmortem human eyes were prepared as per Miyake-Apple posterior video technique, in association with the creation of a scleral window and staining of the capsular bag with trypan blue after phacoemulsification. 3) Two postmortem human eyes were prepared according to the closed-system technique. 4) Two New Zealand rabbits underwent phacoemulsification and bilateral implantation of the accommodative lens. During each procedure, the capsulorhexis size and capsular bag diameter were measured before and after implantation of the IOL using surgical calipers. The distance between the 2 optics of the lens could be measured through the scleral windows. Results:Measurements of the capsulorhexis and capsular bag diameters of the human eyes demonstrated that their shape and size were maintained after implantation of the accommodative lens. No areas of capsular bag distension, zonular stretch or tension could be observed. The lens was secured in the capsular bag in a relatively unaccommodated state. The size of the lenses was found to be relatively large for the capsular bag of the rabbit eyes used. Conclusion:Our preliminary studies suggested that this accommodating IOL design could be implanted in human eyes without capsular bag distortion.
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