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Y Maruyama, T Otani, S Kishi; Intraretinal Fluid Accumulation in Vogt-Koyanagi-Harada Syndrome . Invest. Ophthalmol. Vis. Sci. 2002;43(13):527.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To clarify the nature of serous retinal detachment in Vogt-Koyanagi-Harada (VKH) syndrome. Methods: We examined 40 consecutive eyes of 20 patients with acute VKH syndrome using optical coherence tomography (OCT; Humphrey model 2000) and fluorescein fundus angiography. All eyes had non-rhegmatogenous retinal detachment in the posterior fundus. Cross sectional image of the retina involving the fovea was obtained using OCT in 5.0-mm lengths in all 40 eyes. Results: OCT revealed two types of serous retinal detachment. One was a true serous detachment and the other appeared intraretinal fluid accumulation in the outer retina. Twenty seven eyes had a true serous retinal detachment and 15 eyes had intraretinal fluid accumulation. Two eyes had both features. In 27 eyes with a true serous retinal detachment, subretinal space was optically empty and the detached retina was clearly separated from retinal pigmentary epithelium (RPE) at the outer margin of retinal detachment. The 15 eyes with intraretinal fluid accumulation had one or several oval spaces in the outer retina. A thin reflective layer remained on the RPE, which formed the posterior wall of the oval space. The reflectivity of the oval spaces varied; 11 eyes had scattered reflective dots, and four eyes had an optically empty space. Fluorescein angiography demonstrated diffuse hyperfluorescence in areas of serous retinal detachment and intense dye accumulation in the foci of intraretinal fluid accumulation. Conclusions: Posterior uveitis in VKH syndrome causes two types of serous retinal detachment which included true retinal detachment and intraretinal fluid accumulation.
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